The Plymouth Oesophago-Gastric Cancer Centre sees and treats patients suffering with suspected cancer of the stomach and oesophagus. It is both a local and the tertiary referral service that provides care to patients in the South West Peninsula.  It runs alongside the regional Cardiothoracic Surgery Centre and regional Hepato-Pancreato-Biliary centre, both located here in Plymouth.

The specialist team consists of 5 consultant surgeons, 5 consultant gastroenterologists, 2 consultant oncologists, 4  gastro-intestinal  consultant radiologists, 2 consultant palliative care physicians, 2 upper gastro intestinal cancer nurse specialists, and 2 consultant histopathologists. The surgeons work closely as a single team and provide 24/7 (round the clock) cover for the unit.

Since 2006, minimally invasive oesophagectomy, a keyhole operation, has been performed in Plymouth. This approach has the potential advantage of allowing an earlier recovery after surgery.